Serotonin Transporter (SERT) is a member of the Neurotransmitter-Sodium Symporter (NSS) family and is closely related to transporters for norepinephrine and dopamine, NET, and DAT, respectively. The function of SERT is to take up serotonin (5-HT) released by the activity of serotonergic neurons. It is localized in the central nervous system (CNS) near sites of 5-HT release at terminals and varicosities of serotonergic neurons. In the periphery, SERT is also found on cells in the enteric nervous system and on blood platelets, mast cells, and the syncytiotrophoblast cells of the placenta. Antidepressant drugs (e.g. fluoxetine), as well as drugs of abuse (e.g. cocaine) inhibit SERT.
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