Teplinovivint - CAS# 1428064-91-8


Catalog No. Size PriceQuantity
M16056-C Contact sales@xcessbio.com for quotation $100

Description

Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research.

Product information

CAS Number: 1428064-91-8

Molecular Weight: 442.51

Formula: C25H26N6O2

Chemical Name: N-(6-methoxypyridin-3-yl)-5-{5-[(piperidin-1-yl)methyl]pyridin-3-yl}-1H-indazole-3-carboxamide

Smiles: COC1=CC=C(C=N1)NC(=O)C1=NNC2=CC=C(C=C21)C1=CC(CN2CCCCC2)=CN=C1

InChiKey: YDPWZFPXWFTXNT-UHFFFAOYSA-N

InChi: InChI=1S/C25H26N6O2/c1-33-23-8-6-20(15-27-23)28-25(32)24-21-12-18(5-7-22(21)29-30-24)19-11-17(13-26-14-19)16-31-9-3-2-4-10-31/h5-8,11-15H,2-4,9-10,16H2,1H3,(H,28,32)(H,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 83.33 mg/mL (188.31 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC50=152.9 nM). Teplinovivint inhibits SW480 cells (EC50=25 nM) and primary human mesenchymal stem cells (hMSCs; EC50=10.377 μM). Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC50 between 139-189 nM.

In Vivo:

Teplinovivint (compound 175; 10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model. Teplinovivint (1 mg/ml with 1% BA) has a Tmax of 1 hours in plasma.

Products are for research use only. Not for human use.

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