Alosetron ((Z)-2-butenedioate) - 5-HT Receptor. CAS# 122852-43-1


Catalog No. Size PriceQuantity
M10650-2 Solid 2 mg $85
M10650-10 Solid 10 mg $255

Description

Alosetron (GR 68755) (Z)-2-butenedioate, CAS No. 122852-43-1, is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Z)-2-butenedioate is used for the research of irritable bowel syndrome (IBS). Alosetron (Z)-2-butenedioate blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron (Z)-2-butenedioate attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.

Product information

CAS Number: 122852-43-1

Molecular Weight: 410.42

Formula: C21H22N4O5

Synonym:

GR 68755 ((Z)-2-butenedioate)

GR 68755X ((Z)-2-butenedioate))

Chemical Name: (2Z)-but-2-enedioic acid; 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-1-one

Smiles: CN1C2=CC=CC=C2C2=C1CCN(CC1N=CNC=1C)C2=O.OC(=O)/C=C\C(O)=O

InChiKey: XCPGTDZMQXRLAW-BTJKTKAUSA-N

InChi: InChI=1S/C17H18N4O.C4H4O4/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;5-3(6)1-2-4(7)8/h3-6,10H,7-9H2,1-2H3,(H,18,19);1-2H,(H,5,6)(H,7,8)/b;2-1-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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