Description
BCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI hydrochloride specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI hydrochloride does not inhibit DUSP5.
Product information
CAS Number: 95130-23-7
Molecular Weight: 353.89
Formula: C22H24ClNO
Synonym:
(E)-BCI hydrochloride)
Chemical Name: (2E)-3-(cyclohexylamino)-2-(phenylmethylidene)-2,3-dihydro-1H-inden-1-one hydrochloride
Smiles: Cl.O=C1C2=CC=CC=C2C(NC2CCCCC2)/C/1=C\C1C=CC=CC=1
InChiKey: JPATUDRDKCLPTI-QMGGKDRNSA-N
InChi: InChI=1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H/b20-15+;
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 15.62 mg/mL (44.14 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.
Products are for research use only. Not for human use.
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