Description
Fabesetron (FK1052) is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy.
Product information
CAS Number: 129300-27-2
Molecular Weight: 293.36
Formula: C18H19N3O
Chemical Name: (7R)-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]-6H,7H,8H,9H-pyrido[1,2-a]indol-6-one
Smiles: CC1C2=CC=CC=C2N2C(=O)[C@@H](CC3N=CNC=3C)CCC2=1
InChiKey: AEKQMJRJRAHOAP-CYBMUJFWSA-N
InChi: InChI=1S/C18H19N3O/c1-11-14-5-3-4-6-17(14)21-16(11)8-7-13(18(21)22)9-15-12(2)19-10-20-15/h3-6,10,13H,7-9H2,1-2H3,(H,19,20)/t13-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Fabesetron (FK1052) (0.1 mg/kg p.o.) inhibits completely the increases in the colonic transit. FK1052 (100 µg/kg) completely prevents emesis induced by cisplatin (18 mg/kg, i.p.) in Suncus murinus.
Products are for research use only. Not for human use.
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