Description
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
Product information
CAS Number: 1222490-34-7
Molecular Weight: 725.79
Formula: C42H39N5O7
Chemical Name: (S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5, 11a-dihydro-1H-benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-8-yl)oxy)propoxy)-1, 11a-dihydro-5H-benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-5-one
Smiles: COC1C=CC(=CC=1)C1C[C@H]2C=NC3=CC(OCCCOC4=CC5N=C[C@@H]6CC(=CN6C(=O)C=5C=C4OC)C4C=CC(N)=CC=4)=C(C=C3C(=O)N2C=1)OC
InChiKey: OMRPLUKQNWNZAV-CONSDPRKSA-N
InChi: InChI=1S/C42H39N5O7/c1-50-32-11-7-26(8-12-32)28-16-31-22-45-36-20-40(38(52-3)18-34(36)42(49)47(31)24-28)54-14-4-13-53-39-19-35-33(17-37(39)51-2)41(48)46-23-27(15-30(46)21-44-35)25-5-9-29(43)10-6-25/h5-12,17-24,30-31H,4,13-16,43H2,1-3H3/t30-,31-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I.
Products are for research use only. Not for human use.
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