SGD-1882 - CAS# 1222490-34-7


Catalog No. Size PriceQuantity
M16498-C Contact sales@xcessbio.com for quotation $100

Description

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

Product information

CAS Number: 1222490-34-7

Molecular Weight: 725.79

Formula: C42H39N5O7

Chemical Name: (S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5, 11a-dihydro-1H-benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-8-yl)oxy)propoxy)-1, 11a-dihydro-5H-benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-5-one

Smiles: COC1C=CC(=CC=1)C1C[C@H]2C=NC3=CC(OCCCOC4=CC5N=C[C@@H]6CC(=CN6C(=O)C=5C=C4OC)C4C=CC(N)=CC=4)=C(C=C3C(=O)N2C=1)OC

InChiKey: OMRPLUKQNWNZAV-CONSDPRKSA-N

InChi: InChI=1S/C42H39N5O7/c1-50-32-11-7-26(8-12-32)28-16-31-22-45-36-20-40(38(52-3)18-34(36)42(49)47(31)24-28)54-14-4-13-53-39-19-35-33(17-37(39)51-2)41(48)46-23-27(15-30(46)21-44-35)25-5-9-29(43)10-6-25/h5-12,17-24,30-31H,4,13-16,43H2,1-3H3/t30-,31-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed