Description
EMCS crosslinker, also known as Mal-heptanoic NHS ester, is a non-cleavable, water insoluble, heterobifunctional protein crosslinking reagent that is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies. EMCS crosslinking reagent's NHS ester and maleimide reactive groups react with amino and sulfhydryl moieties, respectively. The EMCS Crosslinker may be useful in the development of antibody drug conjugates (ADCs).
Product information
CAS Number: 55750-63-5
Molecular Weight: 308.29
Formula: C14H16N2O6
Synonym:
EMCS
EMCS Crosslinker
Mal-heptanoic NHS ester
N-[e-Maleimidocaproyloxy]succinimide ester
6-Maleimidohexanoic acid N-hydroxysuccinimide ester
Chemical Name: 2, 5-dioxopyrrolidin-1-yl 6-(2, 5-dioxo-2, 5-dihydro-1H-pyrrol-1-yl)hexanoate
Smiles: O=C(CCCCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O
InChiKey: VLARLSIGSPVYHX-UHFFFAOYSA-N
InChi: InChI=1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 100 mg/mL (324.37 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
6-Maleimidohexanoic acid N-hydroxysuccinimide ester is coupled to the peptides, and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier.
References:
- Shinya Kida, et al. Studies on heterobifunctional cross-linking reagents, 6-maleimidohexanoic acid active esters. Chem Pharm Bull (Tokyo). 2007 Apr;55(4):685-7.
- Shinya Kida, et al. Evaluation of synthetic cell-penetrating peptides, Pro-rich peptide and octaargine derivatives, as adenovirus vector carrier. Protein Pept Lett. 2010 Feb;17(2):164-7.
Products are for research use only. Not for human use.
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