Description
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 133803-81-3
Molecular Weight: 234.29
Formula: C11H22O5
Chemical Name: tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
Smiles: CC(C)(C)OC(=O)CCOCCOCCO
InChiKey: OKOWESVURLUVMD-UHFFFAOYSA-N
InChi: InChI=1S/C11H22O5/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h12H,4-9H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References:
- Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.