Description
m-PEG7-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG7-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Product information
CAS Number: 477775-57-8
Molecular Weight: 418.50
Formula: C16H34O10S
Chemical Name: 2,5,8,11,14,17,20-heptaoxadocosan-22-yl methanesulfonate
Smiles: COCCOCCOCCOCCOCCOCCOCCOS(C)(=O)=O
InChiKey: ABSVPRBGVPHWDJ-UHFFFAOYSA-N
InChi: InChI=1S/C16H34O10S/c1-19-3-4-20-5-6-21-7-8-22-9-10-23-11-12-24-13-14-25-15-16-26-27(2,17)18/h3-16H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References:
- Sanxing Sun, et al. Triazolotriazine derivatives as a2a receptor antagonists. WO2020002969A1.
Products are for research use only. Not for human use.
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