Description
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.
Product information
CAS Number: 5083-84-1
Molecular Weight: 349.81
Formula: C18H20ClNO4
Chemical Name: (9S)-4, 15-dimethoxy-10-azatetracyclo[7.7.1.0, .0, ]heptadeca-1(17), 2(7), 3, 5, 13, 15-hexaene-5, 16-diol hydrochloride
Smiles: Cl.COC1=CC2C3=C4[C@H](CC=2C=C1O)NCCC4=CC(OC)=C3O
InChiKey: POXNVTUOIYRUGG-YDALLXLXSA-N
InChi: InChI=1S/C18H19NO4.ClH/c1-22-14-8-11-10(6-13(14)20)5-12-16-9(3-4-19-12)7-15(23-2)18(21)17(11)16;/h6-8,12,19-21H,3-5H2,1-2H3;1H/t12-;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Norisoboldine hydrochloride (1~30 μM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31. Norisoboldine hydrochloride (30 μM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia. Norisoboldine hydrochloride (1~30 μM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia. Norisoboldine hydrochloride (10, 30 μM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine hydrochloride induces generation of Treg cells in hypoxia.
In Vivo:
Norisoboldine hydrochloride (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment. Norisoboldine hydrochloride (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons.
Products are for research use only. Not for human use.
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