Description
Denopamine ((R)-(-)-Denopamine) is an orally active, selective β1-adrenergic agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects.
Product information
CAS Number: 71771-90-9
Molecular Weight: 317.38
Formula: C18H23NO4
Chemical Name: 4-[(1R)-2-{[2-(3, 4-dimethoxyphenyl)ethyl]amino}-1-hydroxyethyl]phenol
Smiles: COC1=CC=C(CCNC[C@H](O)C2=CC=C(O)C=C2)C=C1OC
InChiKey: VHSBBVZJABQOSG-INIZCTEOSA-N
InChi: InChI=1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Denopamine (0.1-100 μM) suppresses LPS-induced TNF-α production in a concentration-dependent manner.
In Vivo:
Denopamine (14 μmol/kg per day; oral administration; for 14 days) significantly improves the survival of the animals, attenuates myocardial lesions, and suppresses TNF-α production in vivo. The plasma concentration of Denopamine is 13.1±1.9 nmol/L at 1 h, 4.3±0.9 nmol/L at 2 h, 1.8±0.5 nmol/L at 3 h, and <0.6 nmol/L at 5 h after its administration. A single 14 μmol/kg dose of denopamine in mice produces a peak level at 1 h.
References:
- Hayashi M, Ikomi F, Ohhashi T. Noradrenaline-induced smooth muscle relaxation in the specific region of canine facial vein: implications for facial and cranial circulation. J Physiol Sci. 2006 Oct;56(5):369-78. Epub 2006 Oct 12. Erratum in: J Physiol Sci. 2007 Apr;57(2):137. PubMed PMID: 17026784.
- Ohgo T, Okamura H, Noda T, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S, Ohe T, Shimizu W. Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. Heart Rhythm. 2007 Jun;4(6):695-700. Epub 2007 Feb 20. PubMed PMID: 17556186.
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