(Rac)-VU 6008667


Catalog No. Size PriceQuantity
M14090-2 2mg solid $215
M14090-10 10mg solid $780

Description

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration.

Product information

CAS Number: 2092917-63-8

Molecular Weight: 438.85

Formula: C24H17ClF2N2O2

Chemical Name: 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one

Smiles: CC1=CC(=CC=C1Cl)C12C3C=CC=CC=3C(=O)N1CCN2C(=O)C1C=C(F)C(F)=CC=1

InChiKey: XMSLRELXMCKGCB-UHFFFAOYSA-N

InChi: InChI=1S/C24H17ClF2N2O2/c1-14-12-16(7-8-19(14)25)24-18-5-3-2-4-17(18)23(31)29(24)11-10-28(24)22(30)15-6-9-20(26)21(27)13-15/h2-9,12-13H,10-11H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (284.84 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

Products are for research use only. Not for human use.

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