Description
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation.
Product information
CAS Number: 200563-11-7
Molecular Weight: 608.93
Formula: C37H68O6
Chemical Name: (5S)-3-[(13S,15R)-15-[(2R,5R)-2,5-dihydrogenio-5-[(1R)-1-hydroxytridecyl]oxolan-2-yl]-13,15-dihydroxypentadecyl]-5-methyl-2,5-dihydrofuran-2-one
Smiles: C[C@H]1C=C(CCCCCCCCCCCC[C@H](O)C[C@@H](O)[C@H]2CC[C@@H](O2)[C@H](O)CCCCCCCCCCCC)C(=O)O1
InChiKey: ADPAPZVYVYEBGS-CXPQHEJVSA-N
InChi: InChI=1S/C37H68O6/c1-3-4-5-6-7-8-13-16-19-22-25-33(39)35-26-27-36(43-35)34(40)29-32(38)24-21-18-15-12-10-9-11-14-17-20-23-31-28-30(2)42-37(31)41/h28,30,32-36,38-40H,3-27,29H2,1-2H3/t30-,32-,33+,34+,35+,36+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Zhou GX, et al. Calamistrins A and B, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Uvaria calamistrata. J Nat Prod. 1999 Feb;62(2):261-4.
- Li YF, et al. Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism. Yao Xue Xue Bao. 2006 Mar;41(3):252-6.
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