VU6012962


Catalog No. Size PriceQuantity
M14937-2 Contact sales@xcessbio.com for quotation $100

Description

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM.

Product information

CAS Number: 2313526-86-0

Molecular Weight: 448.40

Formula: C21H19F3N4O4

Chemical Name: 4-(cyclopropylmethoxy)-3-methoxy-N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl]benzamide

Smiles: COC1=CC(=CC=C1OCC1CC1)C(=O)NC1C=C(C=CC=1N1C=NC=N1)OC(F)(F)F

InChiKey: IQNLJJLZIVCGFI-UHFFFAOYSA-N

InChi: InChI=1S/C21H19F3N4O4/c1-30-19-8-14(4-7-18(19)31-10-13-2-3-13)20(29)27-16-9-15(32-21(22,23)24)5-6-17(16)28-12-25-11-26-28/h4-9,11-13H,2-3,10H2,1H3,(H,27,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (278.77 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes.

In Vivo:

VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice.

Products are for research use only. Not for human use.

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