Description
VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.
Product information
CAS Number: 2092923-21-0
Molecular Weight: 438.85
Formula: C24H17ClF2N2O2
Chemical Name: (9bS)-9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one
Smiles: CC1=CC(=CC=C1Cl)[C@@]12C3=CC=CC=C3C(=O)N1CCN2C(=O)C1=CC(F)=C(F)C=C1
InChiKey: XMSLRELXMCKGCB-DEOSSOPVSA-N
InChi: InChI=1S/C24H17ClF2N2O2/c1-14-12-16(7-8-19(14)25)24-18-5-3-2-4-17(18)23(31)29(24)11-10-28(24)22(30)15-6-9-20(26)21(27)13-15/h2-9,12-13H,10-11H2,1H3/t24-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (227.87 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
VU 6008667(1 mg/kg或者3mg/kg,口服作用于大鼠)较小的体积(Vss = 7.4 L/kg)和较高的清除率,显示半衰期为2.3小时(t1/2 = 2.3 hr),CLp = 82 mL/min/kg,显示口服生物利用度为17%(17%F)。
Products are for research use only. Not for human use.
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