Description
YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.
Product information
CAS Number: 1804978-81-1
Molecular Weight: 615.74
Formula: C33H37N5O5S
Chemical Name: 3'-({3-[(2-{[2-(dimethylamino)phenyl]formamido}ethyl)amino]phenyl}sulfamoyl)-4'-methoxy-N, N-dimethyl-[1, 1'-biphenyl]-3-carboxamide
Smiles: CN(C)C(=O)C1=CC(=CC=C1)C1=CC(=C(C=C1)OC)S(=O)(=O)NC1=CC(=CC=C1)NCCNC(=O)C1=CC=CC=C1N(C)C
InChiKey: BXJSAMKIFDDLGI-UHFFFAOYSA-N
InChi: InChI=1S/C33H37N5O5S/c1-37(2)29-15-7-6-14-28(29)32(39)35-19-18-34-26-12-9-13-27(22-26)36-44(41,42)31-21-24(16-17-30(31)43-5)23-10-8-11-25(20-23)33(40)38(3)4/h6-17,20-22,34,36H,18-19H2,1-5H3,(H,35,39)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
YNT-185 (20-40 mg/kg; i.p.) increases wakefulness in mice. YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.
Products are for research use only. Not for human use.
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