Description
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively.
Product information
CAS Number: 1783856-40-5
Molecular Weight: 307.27
Formula: C13H9N9O
Chemical Name: 8-[2-(2H-1,2,3,4-tetrazol-5-yl)ethyl]-13-oxa-8,10,12,14,16-pentaazatetracyclo[7.7.0.0²,⁷.0¹¹,¹⁵]hexadeca-1(16),2,4,6,9,11,14-heptaene
Smiles: C(CN1C2=CC=CC=C2C2=NC3=NON=C3N=C12)C1N=NNN=1
InChiKey: GQIVONMEFNDYFD-UHFFFAOYSA-N
InChi: InChI=1S/C13H9N9O/c1-2-4-8-7(3-1)10-13(15-12-11(14-10)18-23-19-12)22(8)6-5-9-16-20-21-17-9/h1-4H,5-6H2,(H,16,17,20,21)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
β-catenin-IN-37 displays Ki values of 17 μM and 18 μM forβ-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.