VRK-IN-1


Catalog No. Size PriceQuantity
M17102-C Contact sales@xcessbio.com for quotation $100
M17102-2 2 mg solid $160
M17102-10 10 mg solid $475
M17102-100 100 mg solid $3,190

Description

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.

Product information

CAS Number: 2378855-09-3

Molecular Weight: 349.28

Formula: C18H11F4NO2

Chemical Name: 4-[5-(3,5-difluoro-4-hydroxyphenyl)-2-methylpyridin-3-yl]-2,6-difluorophenol

Smiles: CC1=NC=C(C=C1C1=CC(F)=C(O)C(F)=C1)C1C=C(F)C(O)=C(F)C=1

InChiKey: PMRGRXLXKYUDIH-UHFFFAOYSA-N

InChi: InChI=1S/C18H11F4NO2/c1-8-12(10-5-15(21)18(25)16(22)6-10)2-11(7-23-8)9-3-13(19)17(24)14(20)4-9/h2-7,24-25H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM.

Products are for research use only. Not for human use.

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