Description
(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1.
Product information
CAS Number: 1228439-71-1
Molecular Weight: 415.50
Formula: C22H25NO5S
Chemical Name: (+)-benzyl 1-acetyl-2-[(4-methanesulfonylphenyl)methyl]pyrrolidine-2-carboxylate
Smiles: CC(=O)N1CCCC1(CC1C=CC(=CC=1)S(C)(=O)=O)C(=O)OCC1C=CC=CC=1
InChiKey: XFXZWVGQXNFWDE-UHFFFAOYSA-N
InChi: InChI=1S/C22H25NO5S/c1-17(24)23-14-6-13-22(23,21(25)28-16-19-7-4-3-5-8-19)15-18-9-11-20(12-10-18)29(2,26)27/h3-5,7-12H,6,13-16H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
(+)-KCC2 blocker 1 ((+)-13), a enantiomers of KCC2 blocker 1, has a 100-fold difference in potency compare with enantiomer (-)-KCC2 blocker 1 ((−)-13)).
Products are for research use only. Not for human use.
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