(±)-H3RESCA-TFP


Catalog No. Size PriceQuantity
M17466-C Contact sales@xcessbio.com for quotation $100

Description

(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine).

Product information

CAS Number: 1919794-40-3

Molecular Weight: 584.51

Formula: C27H28F4N2O8

Chemical Name: 2-[(carboxymethyl)[(1R,2R)-2-[(carboxymethyl)({4-[2-oxo-2-(2,3,5,6-tetrafluorophenoxy)ethyl]phenyl}methyl)amino]cyclohexyl]amino]acetic acid

Smiles: OC(=O)CN(CC1C=CC(CC(=O)OC2C(F)=C(F)C=C(F)C=2F)=CC=1)[C@@H]1CCCC[C@H]1N(CC(O)=O)CC(O)=O |&1:26,31|

InChiKey: GKFBSFKLJKSHSZ-WOJBJXKFSA-N

InChi: InChI=1S/C27H28F4N2O8/c28-17-10-18(29)26(31)27(25(17)30)41-24(40)9-15-5-7-16(8-6-15)11-32(12-21(34)35)19-3-1-2-4-20(19)33(13-22(36)37)14-23(38)39/h5-8,10,19-20H,1-4,9,11-14H2,(H,34,35)(H,36,37)(H,38,39)/t19-,20-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The aluminum fluoride restrained complexing agent (Al18F-RESCA) method combines the chemical advantages of a chelator-based radiolabeling method with the unique physical properties of the radionuclide of choice, fluorine-18. Proteins of interest can be conjugated to RESCA via amine coupling using (±)-H3RESCA-TFP. Al18F-labeled proteins can be obtained with moderate (12-17 GBq/µmol) to good (80-85 GBq/µmol) apparent molar activity, depending on the starting activity of 18F-.

Products are for research use only. Not for human use.

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