YM-750


Catalog No. Size PriceQuantity
M18041-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A.

Product information

CAS Number: 138046-43-2

Molecular Weight: 452.63

Formula: C31H36N2O

Chemical Name: 1-cycloheptyl-1-[(9H-fluoren-2-yl)methyl]-3-(2,4,6-trimethylphenyl)urea

Smiles: CC1C=C(C)C=C(C)C=1NC(=O)N(CC1C=C2CC3=CC=CC=C3C2=CC=1)C1CCCCCC1

InChiKey: FMLJREWZCZHGGW-UHFFFAOYSA-N

InChi: InChI=1S/C31H36N2O/c1-21-16-22(2)30(23(3)17-21)32-31(34)33(27-11-6-4-5-7-12-27)20-24-14-15-29-26(18-24)19-25-10-8-9-13-28(25)29/h8-10,13-18,27H,4-7,11-12,19-20H2,1-3H3,(H,32,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (220.93 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Foam cells accumulated esterified cholesterol (EC) for 24 h in the presence of acLDL without Cu2+, which is suppressed by KY-455 and YM-750.

Products are for research use only. Not for human use.

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