W-84 dibromide


Catalog No. Size PriceQuantity
M18046-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine.

Product information

CAS Number: 21093-51-6

Molecular Weight: 708.52

Formula: C32H44Br2N4O4

Chemical Name: [3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl](6-{[3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl]dimethylazaniumyl}hexyl)dimethylazanium dibromide

Smiles: [Br-].[Br-].C[N+](C)(CCCN1C(=O)C2=CC=CC=C2C1=O)CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O

InChiKey: DZRJZDQAGMZGGA-UHFFFAOYSA-L

InChi: InChI=1S/C32H44N4O4.2BrH/c1-35(2,23-13-19-33-29(37)25-15-7-8-16-26(25)30(33)38)21-11-5-6-12-22-36(3,4)24-14-20-34-31(39)27-17-9-10-18-28(27)32(34)40;;/h7-10,15-18H,5-6,11-14,19-24H2,1-4H3;2*1H/q+2;;/p-2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The stabilizing effect of W-84 (dibromide) on antagonist-receptor complexes may explain the overadditive protective action exerted by the combination of atropine and W-84 (dibromide) against organophosphate intoxication. W-84 (dibromide) not only inhibits radioligand association but also strongly stabilizes antagonist-receptor complexes.

Products are for research use only. Not for human use.

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