(S)-3, 5-DHPG


Catalog No. Size PriceQuantity
M18586-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia.

Product information

CAS Number: 162870-29-3

Molecular Weight: 183.16

Formula: C8H9NO4

Chemical Name: (2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid

Smiles: N[C@@H](C1C=C(O)C=C(O)C=1)C(O)=O

InChiKey: HOOWCUZPEFNHDT-ZETCQYMHSA-N

InChi: InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (545.97 mM; Need ultrasonic). H2O : 25 mg/mL (136.49 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(S)-3,5-DHPG specifically displaces high-affinity quisqualate sites, the putative group I mGlu binding sites.

In Vivo:

(S)-3,5-DHPG (icv; 0.01, 0.1 and 1.0 nmol/5 μL) improves consolidation and retrieval and exhibits anxiolytic activity in dose-dependent manner in male Wistar rats weighing 160-180 g subjected to hypoxia.

Products are for research use only. Not for human use.

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