(S)-MCPG


Catalog No. Size PriceQuantity
M18591-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.

Product information

CAS Number: 150145-89-4

Molecular Weight: 209.20

Formula: C10H11NO4

Chemical Name: 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid

Smiles: C[C@](N)(C1C=CC(=CC=1)C(O)=O)C(O)=O

InChiKey: DNCAZYRLRMTVSF-JTQLQIEISA-N

InChi: InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 1 mg/mL (4.78 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.

In Vivo:

MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.

Products are for research use only. Not for human use.

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