(E)-[6]-Dehydroparadol


Catalog No. Size PriceQuantity
M19721-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(E)--Dehydroparadol, an oxidative metabolite of -Shogaol (HY-14616), is a potent Nrf2 activator. (E)--Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells.

Product information

CAS Number: 878006-06-5

Molecular Weight: 276.37

Formula: C17H24O3

Chemical Name: (1E)-1-(4-hydroxy-3-methoxyphenyl)dec-1-en-3-one

Smiles: CCCCCCCC(=O)/C=C/C1C=C(OC)C(O)=CC=1

InChiKey: AXMBOMODZLJDKX-PKNBQFBNSA-N

InChi: InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h9-13,19H,3-8H2,1-2H3/b11-9+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 140 mg/mL (506.57 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(E)--Dehydroparadol (M15) (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 µM, respectively. (E)--Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells.

In Vivo:

(E)--Dehydroparadol (compound 19) (5 µM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos.

Products are for research use only. Not for human use.

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