Description
YM-58790 is a potent antagonist of M3 muscarinic receptor, with Ki of 15 nM.
Product information
CAS Number: 214558-72-2
Molecular Weight: 466.01
Formula: C27H32ClN3O2
Chemical Name: 1-{[4-(methylamino)phenyl]methyl}piperidin-4-yl N-(diphenylmethyl)carbamate hydrochloride
Smiles: Cl.CNC1=CC=C(CN2CCC(CC2)OC(=O)NC(C2=CC=CC=C2)C2=CC=CC=C2)C=C1
InChiKey: WKHYQXVQUGLLOZ-UHFFFAOYSA-N
InChi: InChI=1S/C27H31N3O2.ClH/c1-28-24-14-12-21(13-15-24)20-30-18-16-25(17-19-30)32-27(31)29-26(22-8-4-2-5-9-22)23-10-6-3-7-11-23;/h2-15,25-26,28H,16-20H2,1H3,(H,29,31);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
YM-58790 shows potent inhibitory effect on urinary bladder contraction, but has little effect on bradycardia. YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion in vitro.
In Vivo:
YM-58790 (3 mg/kg, i.v.) does not inhibit oxotremorine-induced tremor in mice. The effect of YM-58790 on McN-A343-induced pressor in pithed rats, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.
Products are for research use only. Not for human use.
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