Description
ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2.
Product information
CAS Number: 886563-25-3
Molecular Weight: 443.50
Formula: C24H25N7O2
Chemical Name: 2-[({2-[(dimethylcarbamoyl)amino]pyridin-4-yl}methyl)amino]-N-(2-methyl-2H-indazol-6-yl)benzamide
Smiles: CN(C)C(=O)NC1C=C(CNC2=CC=CC=C2C(=O)NC2=CC3=NN(C)C=C3C=C2)C=CN=1
InChiKey: KYNHWVSHYKPILI-UHFFFAOYSA-N
InChi: InChI=1S/C24H25N7O2/c1-30(2)24(33)28-22-12-16(10-11-25-22)14-26-20-7-5-4-6-19(20)23(32)27-18-9-8-17-15-31(3)29-21(17)13-18/h4-13,15,26H,14H2,1-3H3,(H,27,32)(H,25,28,33)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
ZK-261991 inhibits cellular receptor autophosphorylation in KDR-PAECs with an IC50 of 2 nM. ZK991 inhibits VEGFR-3 autophosphorylation concentration dependently with an IC50 of 20 nM.
In Vivo:
ZK991 results in a significantly reduced recruitment of CD11b+ and LYVE-1+ cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation.
Products are for research use only. Not for human use.
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