(Rac)-Calpain Inhibitor XII


Catalog No. Size PriceQuantity
M20991-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

Product information

CAS Number: 181769-57-3

Molecular Weight: 482.57

Formula: C26H34N4O5

Chemical Name: benzyl N-{3-methyl-1-[(1-oxo-1-{[(pyridin-2-yl)methyl]carbamoyl}pentan-2-yl)carbamoyl]butyl}carbamate

Smiles: CC(C)CC(NC(=O)OCC1=CC=CC=C1)C(=O)NC(CCC)C(=O)C(=O)NCC1C=CC=CN=1

InChiKey: PLVWMBFPIAQRHK-UHFFFAOYSA-N

InChi: InChI=1S/C26H34N4O5/c1-4-10-21(23(31)25(33)28-16-20-13-8-9-14-27-20)29-24(32)22(15-18(2)3)30-26(34)35-17-19-11-6-5-7-12-19/h5-9,11-14,18,21-22H,4,10,15-17H2,1-3H3,(H,28,33)(H,29,32)(H,30,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 16 mg/mL (33.16 mM; Need ultrasonic and warming).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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