WAY-151932


Catalog No. Size PriceQuantity
M21933-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

Product information

CAS Number: 220460-92-4

Molecular Weight: 402.88

Formula: C23H19ClN4O

Chemical Name: 9-[2-chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-3,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),4,6,10,12-pentaene

Smiles: CC1C=CN(N=1)C1C=C(Cl)C(=CC=1)C(=O)N1CC2=CC=CN2CC2=CC=CC=C12

InChiKey: JXKQHDZUZGKDGO-UHFFFAOYSA-N

InChi: InChI=1S/C23H19ClN4O/c1-16-10-12-28(25-16)18-8-9-20(21(24)13-18)23(29)27-15-19-6-4-11-26(19)14-17-5-2-3-7-22(17)27/h2-13H,14-15H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 200 mg/mL (496.43 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV2 receptors in a dose-dependent manner with an EC50 of 0.74±0.07 nM.

In Vivo:

Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED50=0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.

Products are for research use only. Not for human use.

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