Description
(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK.DNA-PK|7-30 nM (IC50) Rac-Nedisertib (Compound 135) less actively inhibits DNA-PK, with an IC50 in the range of 7-30 nM. . Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.
Product information
CAS Number: 1637542-32-5
Molecular Weight: 481.91
Formula: C24H21ClFN5O3
Chemical Name: (R)-{2-chloro-4-fluoro-5-[7-(morpholin-4-yl)quinazolin-4-yl]phenyl}(6-methoxypyridazin-3-yl)methanol
Smiles: COC1C=CC(=NN=1)[C@H](O)C1C=C(C(F)=CC=1Cl)C1N=CN=C2C=C(C=CC=12)N1CCOCC1
InChiKey: MOWXJLUYGFNTAL-XMMPIXPASA-N
InChi: InChI=1S/C24H21ClFN5O3/c1-33-22-5-4-20(29-30-22)24(32)16-11-17(19(26)12-18(16)25)23-15-3-2-14(10-21(15)27-13-28-23)31-6-8-34-9-7-31/h2-5,10-13,24,32H,6-9H2,1H3/t24-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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