Description
EC50: 5.4 nM for RSV fusion VP-14637 is an inhibitor of RSV. Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. RSV F protein that mediates fusion of the viral envelope with the host cell membrane has become a target of anti-RSV treatment. In vitro: Previous study demonstrated that VP-14637 did not block RSV adsorption but inhibited RSV-induced cell-cell fusion and specifically bound to RSV-infected cells. VP-14637 was capable of specifically interacting with the RSV fusion protein. RSV variants resistant to VP-14637 were selected, in which no mutations arose in HR1, indicating a mechanism other than direct disruption of the heptad repeat interaction. The F proteins containing the resistance mutations exhibited greatly reduced binding of VP-14637 . In vivo: In cotton rats, animals given as little as 126 microg/kg of VP-14637 by small droplet aerosol starting 1 day after experimental virus infection with either a RSV A or B subtype consistently had significantly lower mean pulmonary RSV titers and reduced histopathological findings than mock-treated animals or cotton rats given placebo. In addition, no cotton rat treated with VP14637 had any evident untoward responses . Clinical trial: So far, no clinical study has been conducted.
Product information
CAS Number: 235106-62-4
Molecular Weight: 510.51
Formula: C25H22N10O3
Chemical Name: 2-({2-hydroxy-5-[(1E)-[(5-methyl-1H-1,2,3,4-tetrazol-1-yl)imino]methyl]phenyl}(4-hydroxyphenyl)methyl)-4-[(1Z)-[(5-methyl-1H-1,2,3,4-tetrazol-1-yl)imino]methyl]phenol
Smiles: CC1=NN=NN1/N=C\C1C=C(C(C2=CC(/C=N/N3N=NN=C3C)=CC=C2O)C2C=CC(O)=CC=2)C(O)=CC=1
InChiKey: BLUJRJMLDHEMRX-VVCLLGATSA-N
InChi: InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3/b26-13-,27-14+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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