(R)-SCH 42495


Catalog No. Size PriceQuantity
M26032-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354.

Product information

CAS Number: 156792-25-5

Molecular Weight: 411.58

Formula: C20H29NO4S2

Chemical Name: ethyl (2S)-2-[(2R)-2-[(acetylsulfanyl)methyl]-3-(2-methylphenyl)propanamido]-4-(methylsulfanyl)butanoate

Smiles: CSCC[C@H](NC(=O)[C@H](CSC(C)=O)CC1=CC=CC=C1C)C(=O)OCC

InChiKey: ZVQXPUMRSJGLSF-ROUUACIJSA-N

InChi: InChI=1S/C20H29NO4S2/c1-5-25-20(24)18(10-11-26-4)21-19(23)17(13-27-15(3)22)12-16-9-7-6-8-14(16)2/h6-9,17-18H,5,10-13H2,1-4H3,(H,21,23)/t17-,18-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NEP acts as a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro.

In Vivo:

Inhibition of NEP in vivo has been shown to produce beneficial vasodilatory and natriuretic responses.

Products are for research use only. Not for human use.

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