ω-Agatoxin IVA

ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels.

Product information

CAS Number: 145017-83-0

Molecular Weight: 5202.25

Formula: C217H360N68O60S10

Chemical Name: 4-{2-[2-(2-{2-[(1-{6-amino-2-[(87-{6-amino-2-[6-amino-2-(2,6-diaminohexanamido)hexanamido]hexanamido}-60,78-bis(4-aminobutyl)-4,13,84-tris(butan-2-yl)-66,95,101-tris(3-carbamimidamidopropyl)-25-(carbamoylmethyl)-31-(2-carboxyethyl)-75-(carboxymethyl)-22,48-bis(1-hydroxyethyl)-10-(hydroxymethyl)-72-[(4-hydroxyphenyl)methyl]-57-[(1H-indol-3-yl)methyl]-81-methyl-16-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,17,20,23,26,29,32,41,47,50,53,56,59,62,65,68,71,74,77,80,83,86,93,96,99,102,105,112-dotriacontaoxo-36,37,89,90,108,109,114,115-octathia-3,6,9,12,15,18,21,24,27,30,33,40,46,49,52,55,58,61,64,67,70,73,76,79,82,85,94,97,100,103,106,111-dotriacontaazapentacyclo[61.43.4.4⁷,²⁸.2³⁹,⁹².0⁴²,⁴⁶]116n-34-yl)formamido]hexanoyl}pyrrolidin-2-yl)formamido]-5-carbamimidamidopentanamido}-4-methylpentanamido)-3-methylpentanamido]-4-(methylsulfanyl)butanamido}-4-({[(1-{[({1-[(1-carboxyethyl)carbamoyl]-3-methylbutyl}carbamoyl)methyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)butanoic acid

Smiles: CC(O)C1NC(=O)CNC(=O)C(CCSC)NC(=O)C(NC(=O)C(CO)NC(=O)C2CSSCC(NC(=O)C(CC(N)=O)NC1=O)C(=O)NC(CCC(O)=O)C(=O)NC(CSSCC1NC(=O)C3CCCN3C(=O)C(NC(=O)CNC(=O)CNC(=O)C(CC3=CNC4=CC=CC=C34)NC(=O)C(CCCCN)NC(=O)C3CSSCC(NC(=O)CNC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(CCCNC(N)=N)NC(=O)C(CSSCC(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(N)CCCCN)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CC(O)=O)C(=O)NC(CC4C=CC(O)=CC=4)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)N3)NC1=O)C(=O)NC(C(C)CC)C(=O)N2)C(C)O)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(O)=O)C(C)CC

InChiKey: NVVFOMZVLALQKT-UHFFFAOYSA-N

InChi: InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-348-100-146-202(333)283-171(114(14)24-4)209(340)277-152-106-354-350-102-148(274-192(323)143(88-156(225)290)269-210(341)172(117(17)287)278-164(298)98-244-179(310)135(67-81-346-19)262-207(338)170(113(13)23-3)281-195(326)145(99-286)270-200(152)331)198(329)260-134(64-66-166(301)302)189(320)272-150(199(330)264-137(52-32-38-74-223)211(342)284-79-43-57-154(284)204(335)261-132(56-42-78-237-217(232)233)187(318)265-140(85-110(9)10)194(325)280-169(112(12)22-2)208(339)263-136(68-82-347-20)190(321)259-133(63-65-165(299)300)178(309)243-95-160(294)251-138(83-108(5)6)180(311)245-96-161(295)252-139(84-109(7)8)191(322)248-116(16)213(344)345)104-352-353-105-151(276-205(336)155-58-44-80-285(155)212(343)173(118(18)288)279-163(297)92-239-157(291)91-240-182(313)142(87-120-90-238-124-47-26-25-45-122(120)124)267-186(317)130(258-197(147)328)50-30-36-72-221)201(332)275-149(196(327)256-126(54-40-76-235-215(228)229)177(308)242-93-158(292)249-125(53-39-75-234-214(226)227)176(307)241-97-162(296)253-146)103-351-355-107-153(203(334)282-168)273-188(319)131(51-31-37-73-222)257-184(315)129(49-29-35-71-220)255-175(306)123(224)46-27-33-69-218/h25-26,45,47,59-62,90,108-118,123,125-155,168-173,238,286-289H,21-24,27-44,46,48-58,63-89,91-107,218-224H2,1-20H3,(H2,225,290)(H,239,291)(H,240,313)(H,241,307)(H,242,308)(H,243,309)(H,244,310)(H,245,311)(H,246,312)(H,247,337)(H,248,322)(H,249,292)(H,250,293)(H,251,294)(H,252,295)(H,253,296)(H,254,305)(H,255,306)(H,256,327)(H,257,315)(H,258,328)(H,259,321)(H,260,329)(H,261,335)(H,262,338)(H,263,339)(H,264,330)(H,265,318)(H,266,324)(H,267,317)(H,268,316)(H,269,341)(H,270,331)(H,271,314)(H,272,320)(H,273,319)(H,274,323)(H,275,332)(H,276,336)(H,277,340)(H,278,298)(H,279,297)(H,280,325)(H,281,326)(H,282,334)(H,283,333)(H,299,300)(H,301,302)(H,303,304)(H,344,345)(H4,226,227,234)(H4,228,229,235)(H4,230,231,236)(H4,232,233,237)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.