VP3.15 dihydrobromide


Catalog No. Size PriceQuantity
M28494-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).

Product information

CAS Number: 1281681-33-1

Molecular Weight: 528.30

Formula: C20H24Br2N4OS

Chemical Name: N-(2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazol-5-ylidene)-2-(morpholin-4-yl)ethan-1-amine dihydrobromide

Smiles: Br.Br.C(CN=C1N=C(C2C=CC=CC=2)N(S1)C1C=CC=CC=1)N1CCOCC1

InChiKey: CAJZOXQDSKOPBU-SERMZQFOSA-N

InChi: InChI=1S/C20H22N4OS.2BrH/c1-3-7-17(8-4-1)19-22-20(21-11-12-23-13-15-25-16-14-23)26-24(19)18-9-5-2-6-10-18;;/h1-10H,11-16H2;2*1H/b21-20+;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (118.30 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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