Description
(S)-ErSO is the dextrorotatory enantiomer of ErSO. (S)-ErSO is inactive in MCF-7 cells (from patent WO2020009958A1, compound (s)-105).
Product information
CAS Number: 2407860-34-6
Molecular Weight: 453.33
Formula: C22H13F6NO3
Chemical Name: 2H-Indol-2-one, 1, 3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3S)-
Smiles: OC1C=CC(=CC=1)[C@]1(C(=O)NC2C1=CC=CC=2C(F)(F)F)C1C=CC(=CC=1)OC(F)(F)F
InChiKey: ZFSRXAHDJSCEDS-FQEVSTJZSA-N
InChi: InChI=1S/C22H13F6NO3/c23-21(24,25)17-3-1-2-16-18(17)29-19(31)20(16,12-4-8-14(30)9-5-12)13-6-10-15(11-7-13)32-22(26,27)28/h1-11,30H,(H,29,31)/t20-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
(-)-ErSO induces dose-dependent death of MCF-7 cells. (+)-l05 is inactive.
References:
- David J. Shapiro, et al. Activators of the unfolded protein response. WO2020009958A1.
Products are for research use only. Not for human use.
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