Description
VS-15, a IDO1 inhibitor, selectively binds the heme-free form of IDO1. VS-15 is described as an iNOS inhibitor based on the reduction of NO production.
Product information
CAS Number: 951948-78-0
Molecular Weight: 493.56
Formula: C29H27N5O3
Smiles: O=C(NCCC1=CNC2=CC=CC=C12)C(=O)NC1=CC=CC=C1C(=O)NCCC1=CNC2=CC=CC=C12
InChiKey: ZOFGOTNKENWHRR-UHFFFAOYSA-N
InChi: InChI=1S/C29H27N5O3/c35-27(30-15-13-19-17-32-24-10-4-1-7-21(19)24)23-9-3-6-12-26(23)34-29(37)28(36)31-16-14-20-18-33-25-11-5-2-8-22(20)25/h1-12,17-18,32-33H,13-16H2,(H,30,35)(H,31,36)(H,34,37)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
VS-15 reduces the IDO1-mediated signaling pathway by negatively interfering with its partnership with SHPs and PI3K regulatory subunit p85 as well as with the IDO1 anchoring to the early endosomes in tumor cells. VS-15 counteracts the TGF-β-mediated immunosuppressive phenotype in dendritic cells and reduces the level of inhibition of T cell proliferation by suppressive monocytes isolated from patients affected by pancreatic cancer.
Products are for research use only. Not for human use.
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