Rutin

Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress

Product information

CAS Number: 153-18-4

Molecular Weight: 610.52

Formula: C27H30O16

Synonym:

Rutoside

Birutan

Eldrin

Oxyritin

Paliuroside

Sophorin

Venoruton

Yunxianggan

Chemical Name: 2-(3, 4-dihydroxyphenyl)-5, 7-dihydroxy-3-{[(2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-({[(2R, 3R, 4R, 5R, 6S)-3, 4, 5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one

Smiles: C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3C(=O)C4=C(C=C(O)C=C4O)OC=3C3=CC(O)=C(O)C=C3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

InChiKey: IKGXIBQEEMLURG-NVPNHPEKSA-N

InChi: InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL(163.79 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human. Rutin inhibits platelet aggregation as well as decreases capillary permeability, making the blood thinner and improving circulation. Recent studies show rutin could help prevent blood clots, so could be used to treat patients at risk of heart attacks and strokes.

In Vivo:

LD50: Mice 650mg/kg (i.p.)

References:

1. Ortolani O, et al. Transplant Proc, 1995, 27(5), 2877-2878.
2. Navarro-Nunez L, et al. J Agric Food Chem, 2008, 56(9), 2970-2976.

Products are for research use only. Not for human use.