Honokiol DCA - CAS# 1620160-42-0


Catalog No. Size PriceQuantity
M16668-C Contact sales@xcessbio.com for quotation $100

Description

Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level.

Product information

CAS Number: 1620160-42-0

Molecular Weight: 488.19

Formula: C22H18Cl4O4

Chemical Name: 4-[(2,2-dichloroacetyl)oxy]-3,5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2-yl 2,2-dichloroacetate

Smiles: C=CCC1=C(OC(=O)C(Cl)Cl)C(=CC(CC=C)=C1OC(=O)C(Cl)Cl)C1C=CC=CC=1

InChiKey: MLWDVCIMRMORNB-UHFFFAOYSA-N

InChi: InChI=1S/C22H18Cl4O4/c1-3-8-14-12-16(13-10-6-5-7-11-13)18(30-22(28)20(25)26)15(9-4-2)17(14)29-21(27)19(23)24/h3-7,10-12,19-20H,1-2,8-9H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Honokiol DCA (20-40 μM; 24-48 h) inhibits the viability of LNCaP and C4-2 cells in a dose-and time-dependent manner. Honokiol DCA (5-20 μM; 10 days) inhibits clonogenicity of prostate cancer cells. Honokiol DCA (20-40 μM; 24-48 h) significantly decreases the level of androgen receptor (AR) and prostate specific antigen (PSA) protein in LNCaP cells. Honokiol DCA (40 μM; 24 h) significantly decreases AR promoter activity in LNCaP and C4-2 cells.

In Vivo:

Honokiol类似物

Products are for research use only. Not for human use.

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