Description
HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor against human head and neck squamous cell carcinoma (HNSCC).
Product information
CAS Number: 1420290-99-8
Molecular Weight: 406.65
Formula: C15H14Cl3N3O4
Synonym:
HJC0152 hydrochloride
HJC0152
1420290-99-8
2-(2-Aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide HCl
2-(2-Amino-ethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Hydrochloride
Chemical Name: 2-(2-Amino-ethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Hydrochloride
Smiles: Cl.NCCOC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(C=C1Cl)[N+]([O-])=O
InChiKey: XRZHLOYBZOONSZ-UHFFFAOYSA-N
InChi: InChI=1S/C15H13Cl2N3O4.ClH/c16-9-1-4-14(24-6-5-18)11(7-9)15(21)19-13-3-2-10(20(22)23)8-12(13)17;/h1-4,7-8H,5-6,18H2,(H,19,21);1H
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Wang Y, Wang S, Wu Y, Ren Y, Li Z, Yao X, Zhang C, Ye N, Jing C, Dong J, Zhang K, Sun S, Zhao M, Guo W, Qu X, Qiao Y, Chen H, Kong L, Jin R, Wang X, Zhang L, Zhou J, Shen Q, Zhou X. Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152. Mol Cancer Ther. 2017 Apr;16(4):578-590. doi: 10.1158/1535-7163.MCT-16-0606. Epub 2017 Jan 30. PubMed PMID: 28138036; PubMed Central PMCID: PMC5380531.
Products are for research use only. Not for human use.
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