Description
m-3M3FBS is a novel phospholipase C activator. It can be developed as a novel anti-leukemic agent.
Product information
CAS Number: 200933-14-8
Molecular Weight: 343.36
Formula: C16H16F3NO2S
Chemical Name: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide
Smiles: CC1C=C(C)C=C(C)C=1S(=O)(=O)NC1=CC(=CC=C1)C(F)(F)F
InChiKey: ZIIUUSVHCHPIQD-UHFFFAOYSA-N
InChi: InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (291.24 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells. m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis.
References:
- Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63(5):1043-1050.
- Krjukova J, et al. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol. 2004;143(1):3-7.
- Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222(2):227-235.
Products are for research use only. Not for human use.
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