MK-4827 Tosylate


Catalog No. Size PriceQuantity
M9049-2 Solid 2 mg $95
M9049-10 Solid 10 mg $285

Description

Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.

Product information

CAS Number: 1038915-73-9

Molecular Weight: 492.59

Formula: C26H28N4O4S

Synonym:

Niraparib tosylate

MK 4827 tosylate

MK4827 tosylate

Chemical Name: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide; 4-methylbenzene-1-sulfonic acid

Smiles: CC1C=CC(=CC=1)S(O)(=O)=O.NC(=O)C1=CC=CC2=CN(N=C21)C1C=CC(=CC=1)[C@H]1CNCCC1

InChiKey: LCPFHXWLJMNKNC-PFEQFJNWSA-N

InChi: InChI=1S/C19H20N4O.C7H8O3S/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)/t14-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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