Description
Kobe0065 is a small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Kobe0065 also inhibits tumor growth in SW480 colon cancer cell xenografts.
Product information
CAS Number: 436133-68-5
Molecular Weight: 449.79
Formula: C15H11ClF3N5O4S
Chemical Name: 3-(3-chloro-4-methylphenyl)-1-{[2,6-dinitro-4-(trifluoromethyl)phenyl]amino}thiourea
Smiles: CC1=CC=C(C=C1Cl)NC(=S)NNC1C(=CC(=CC=1[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O
InChiKey: KSJVAYBCXSURMQ-UHFFFAOYSA-N
InChi: InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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