Reversine


Catalog No. Size PriceQuantity
M10364-2 Solid 2 mg $85
M10364-10 Solid 10 mg $255

Description

Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Similarly to the Aurora kinase inhibitor VX-680, reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia but was significantly less toxic than VX-680 on cells from healthy donors.

Product information

CAS Number: 656820-32-5

Molecular Weight: 393.49

Formula: C21H27N7O

Chemical Name: N6-cyclohexyl-N2-[4-(morpholin-4-yl)phenyl]-7H-purine-2,6-diamine

Smiles: C1CN(CCO1)C1C=CC(=CC=1)NC1N=C2N=CNC2=C(NC2CCCCC2)N=1

InChiKey: ZFLJHSQHILSNCM-UHFFFAOYSA-N

InChi: InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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