Description
AT-101 is a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines.
Product information
CAS Number: 90141-22-3
Molecular Weight: 518.55
Formula: C30H30O8
Synonym:
Cottonseed Meal Toxin
Gossypol
BL 193
BL-193
BL193
NSC 56817
NSC 624336
Pogosin
(R)-(-)-Gossypol
R-(-)-gossypol acetic acid
AT 101
AT101
Related CAS Number:
12542-36-8 (Gossypol acetic acid)
303-45-7 (Gossypol(RS))
Chemical Name: [2, 2'-Binaphthalene]-8, 8'-dicarboxaldehyde, 1, 1', 6, 6', 7, 7'-hexahydroxy-3, 3'-dimethyl-5, 5'-bis(1-methylethyl)-, (2R)-
Smiles: CC1=CC2C(=C(C=O)C(O)=C(O)C=2C(C)C)C(O)=C1C1=C(O)C2C(C=O)=C(O)C(O)=C(C(C)C)C=2C=C1C
InChiKey: QBKSWRVVCFFDOT-UHFFFAOYSA-N
InChi: InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. [2]. Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.