Description
c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1, Compound Example 7. c-Fms-IN-9 inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively.
Product information
CAS Number: 1628574-50-4
Molecular Weight: 405.45
Formula: C21H23N7O2
Chemical Name: 3-tert-butyl-1-(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one
Smiles: CN1C=C(C=N1)C1=CC(=CC=N1)OC1=CC=C(N=C1C)N1N=C(NC1=O)C(C)(C)C
InChiKey: DKZTVZFTPXVEJW-UHFFFAOYSA-N
InChi: InChI=1S/C21H23N7O2/c1-13-17(30-15-8-9-22-16(10-15)14-11-23-27(5)12-14)6-7-18(24-13)28-20(29)25-19(26-28)21(2,3)4/h6-12H,1-5H3,(H,25,26,29)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
c-Fms-IN-9 inhibits M-NFS-60, THP-1 and osteoclast cells proliferation with IC50s of 0.01-0.1 μM.
Products are for research use only. Not for human use.
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