Description
PROTAC c-Met degrader-1 (Compound Met-DD4) is an orally active PROTAC degrader for c-Met with a DC50 of 6.21 nM. PROTAC c-Met degrader-1 inhibits the proliferation of c-Met-addicted cell MKN-45 with an IC50 of 4.37 nM, and arrests the cell cycle at G0/G1 phase. PROTAC c-Met degrader-1 exhibits antitumor efficacy in MKN-45 xenograft mouse models.
Product information
CAS Number: 3056647-52-7
Molecular Weight: 820.87
Formula: C45H41FN10O5
Smiles: O=C1CCC(C(=O)N1)N1C(=O)C2=CC(=CC=C2C1=O)N1CCN(CC2CCN(CC2)C(=O)C2=CC=C(C=C2F)C2C=NC3=NC=C(CC4=CC5=CC=CN=C5C=C4)N3N=2)CC1
InChiKey: YSTQEPBPZJFTEG-UHFFFAOYSA-N
InChi: InChI=1S/C45H41FN10O5/c46-36-22-30(38-25-49-45-48-24-32(56(45)51-38)21-28-3-8-37-29(20-28)2-1-13-47-37)4-6-34(36)42(59)54-14-11-27(12-15-54)26-52-16-18-53(19-17-52)31-5-7-33-35(23-31)44(61)55(43(33)60)39-9-10-40(57)50-41(39)58/h1-8,13,20,22-25,27,39H,9-12,14-19,21,26H2,(H,50,57,58)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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