CB1 inverse agonist 1 - CAS# 852315-00-5


Catalog No. Size PriceQuantity
M17418-C Contact sales@xcessbio.com for quotation $100

Description

CB1 inverse agonist 1 is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.

Product information

CAS Number: 852315-00-5

Molecular Weight: 514.79

Formula: C25H18Cl3N3O3

Chemical Name: N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

Smiles: CC(=O)C1=C(NC(C)=O)C2=CC(=C(N=C2N(C)C1=O)C1=CC=C(Cl)C=C1Cl)C1C=CC(Cl)=CC=1

InChiKey: VHSIAYLBCLUAFT-UHFFFAOYSA-N

InChi: InChI=1S/C25H18Cl3N3O3/c1-12(32)21-23(29-13(2)33)19-11-18(14-4-6-15(26)7-5-14)22(30-24(19)31(3)25(21)34)17-9-8-16(27)10-20(17)28/h4-11H,1-3H3,(H,29,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

CB1 inverse agonist 1 (Compound 14; 0.3, 1, or 3 mg/kg)inhibits feeding in a dose-dependent manner. The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively.

Products are for research use only. Not for human use.

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