Description
KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity.
Product information
CAS Number: 2138882-71-8
Molecular Weight: 335.16
Formula: C15H9Cl2FN4
Chemical Name: 4,6-dichloro-N-{4'-fluoro-[1,1'-biphenyl]-4-yl}-1,3,5-triazin-2-amine
Smiles: FC1C=CC(=CC=1)C1C=CC(=CC=1)NC1N=C(Cl)N=C(Cl)N=1
InChiKey: DUROVTLUQOYUPH-UHFFFAOYSA-N
InChi: InChI=1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (298.36 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3. KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation. KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death. KEA1-97 (231MFP cells) resistants to survival and proliferation impairments.
In Vivo:
KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth.
Products are for research use only. Not for human use.
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