Description
NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer.
Product information
CAS Number: 6837-93-0
Molecular Weight: 473.50
Formula: C17H15NO9S3
Chemical Name: 4-amino-5-[(4-methylbenzenesulfonyl)oxy]naphthalene-2,7-disulfonic acid
Smiles: CC1C=CC(=CC=1)S(=O)(=O)OC1C=C(C=C2C=C(C=C(N)C2=1)S(O)(=O)=O)S(O)(=O)=O
InChiKey: ZIQWUYNDHGXLIN-UHFFFAOYSA-N
InChi: InChI=1S/C17H15NO9S3/c1-10-2-4-12(5-3-10)30(25,26)27-16-9-14(29(22,23)24)7-11-6-13(28(19,20)21)8-15(18)17(11)16/h2-9H,18H2,1H3,(H,19,20,21)(H,22,23,24)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 31.25 mg/mL (66.00 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.
In Vivo:
NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts.
References:
- Arora S, et al. Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget. 2016 Nov 15;7(46):75104-75117.
Products are for research use only. Not for human use.
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