Description
THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.
Product information
CAS Number: 1621523-07-6
Molecular Weight: 568.07
Formula: C31H30ClN7O2
Chemical Name: N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[4-(dimethylamino)butanamido]benzamide
Smiles: CN(C)CCCC(=O)NC1C=CC(=CC=1)C(=O)NC1C=C(C=CC=1)NC1N=C(C(Cl)=CN=1)C1=CNC2=CC=CC=C21
InChiKey: TUERFPPIPKZNKE-UHFFFAOYSA-N
InChi: InChI=1S/C31H30ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-5,7-10,12-15,17-19,33H,6,11,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 100 mg/mL (176.03 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM.
Products are for research use only. Not for human use.
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